INFLUENCE OF SUMEDAZOLE ON THE GENERAL CONDITION AND MORPHOLOGICAL COMPOSITION OF SHEEP BLOOD

Received 30.09.2024
Revised 03.12.2024
Published 29.12.2024

Abstract

The conducted experimental studies had the aim of which was to identify the effect of the new anthelmintic sumedazole when administered orally in helminthicidal (100 mg/kg) and three-fold increased (300 mg/kg) doses on the general condition and morphological composition of the blood of sheep. Eight ewes and one three-year-old wether of the local breed were used for the experiments  of average fatness, which were divided into 3 groups of 3 animals each, based on the principle of analogs. Before the drug was given and on the second and fifth days after its administration, pulse, respiratory movements and body temperature were measured using conventional methods and blood was taken from the jugular vein. Sumedazole in the indicated doses does not have a significant effect on the general condition indicators and morphological composition of the blood in sheep. The observed differences between the experimental and control data are not statistically significant (P ≥ 0.05)

Keywords

sumedazole anthelmintic general condition sheep blood
Suggested citation
Isakova, K., Arzybaev, M., Shiytyeva, N., Malabaeva, A., & Azhybekov, N. (2024). INFLUENCE OF SUMEDAZOLE ON THE GENERAL CONDITION AND MORPHOLOGICAL COMPOSITION OF SHEEP BLOOD. Bulletin of the Kyrgyz National Agrarian University, 22(6), 367-371.

References

  1. Agadzhanyan, N.A., & Korobkov, A.V. (1983). Workshop on normal physiology: A textbook for medical universities. Moscow: Vysshaya Shkola.
  2. Workshop on the course "Human and Animal Physiology". (2013). Moscow.
  3. Azhybekov, N.A. (2010). Abstract of PhD in Veterinary Sciences dissertation. Moscow.
  4. Aldashev, A.A., & Rakhimova, I.A. (1983). Anthelmintics. Frunze.
  5. Arkhipov, I.A. (2009). Anthelmintics: Pharmacology and application. Moscow.
  6. Arzybaev, M., Isakova, K.S., Shyiytyeva, N., & Malabaeva, A.M. (2020). Pharmacological screening of new complex compounds of imidazole for anthelmintic activity. Bulletin of Osh State University, 5, 46-52.
  7. Arkhipov, I.A., Khalikov, S.S., Dushkin, A.V., Varlamova, A.I., Musaev, M.B., Polyakov, N.E., Chistyachenko, Y.S., Sadov, K.M., & Khalikov, M.S. (2017). Supramolecular complexes of anthelmintic benzimidazole drugs, preparation and properties. Moscow: Novye Avtory.
  8. Babakulov, M.N. (2005). Nematodoses of sheep and improvement of control measures in the south of Kyrgyzstan. (Abstract of Doctor of Veterinary Sciences dissertation, Bishkek, Kyrgyz Republic).
  9. Tursunov, T.T. (2000). Main trichostrongylidoses of sheep in the eastern zone of the Issyk-Kul basin and control measures. (Abstract of PhD in Veterinary Sciences dissertation).
  10. Varlamova, A.I., & Arkhipov, I.A. (2018). Homeostasis indicators in cattle after application of a supramolecular complex of fenbendazole. Russian Parasitology Journal, 12(1), 64-69.
  11. Demidov, N.B. (1982). Anthelmintics in veterinary medicine. Moscow: Kolos.
  12. Didenko, P.P. (1993). Modern aspects of the search for new anthelmintics, their dosage forms and chemotherapy of the most common helminthiases in sheep. (Abstract of Doctor of Sciences dissertation, Moscow, Russia).
  13. Kasyimbekov, B.K. (1990). Main helminthiases of ruminants in Kyrgyzstan and control measures. (Abstract of Doctor of Veterinary Sciences dissertation, Moscow, Russia).
  14. Kozlov, S.A., & Musaev, M.B. (2015). The effect of the anthelmintic mitranox on hematological and biochemical parameters of rat blood in a subchronic experiment. Russian Parasitology Journal, 4, 19-21.
  15. Myastsova, T.Y. (2020). The effect of the complex anthelmintic triclamizole on some hematological and biochemical parameters of laboratory animals. Epizootology, Immunobiology, Pharmacology, Sanitation, 2, 69-75.
  16. Salykov, R.S. (2003). Toxicological and pharmacological characteristics of polymedol. (Abstract of Doctor of Veterinary Sciences dissertation, Bishkek, Kyrgyz Republic).
  17. Patent No. 2280. (2022). Use of the compound hexaaquahexaimidazole copper (II) sulfate [C11SO4:6C3H4N26:6H2O] as an anthelmintic agent. Kyrgyz Republic.
  18. Shevchenko, I.T., Bogatov, O.P., & Khripta, F.P. (1970). Elements of variation statistics for physicians. Kiev.
  19. Teruel, M., Dercole, J., & Catalano, R. (2011). Evaluation of potential embryo toxicity of albendazole sulphoxide in CF1 mice. Biocell, 35(1), 29-33.
  20. Carlsson, G., Patring, J., Ullerås, E., & Oskarsson, A. (2011). Developmental toxicity of albendazole and its three main metabolites in zebrafish embryos. Reproductive Toxicology, 32(1), 129-137.
  21. Hosseinzadeh, Z., Ramazan, A., & Razzaghi-Asl, N. (2018). Anti-cancer nitrogen-containing heterocyclic compounds. Current Organic Chemistry, 22, 2256-2279.
  22. Theodorides, V.J., Gyurik, R.J., Kingsbury, W.D., & Parish, R.C. (1976). Anthelmintic activity of albendazole against liver flukes, tapeworms, lung and gastrointestinal roundworms. Experientia, 32(6), 702-703.