Abstract
The study was carried out on 60 white Wistar rats, simulating a surgical wound. The rats were divided into 5 groups of 6 rats each. Group 1 — control, rats from this group made an incision on the side wall, abdominal wall, followed by natural healing within 10 days; Group 2 — an incision followed by the use of chitosan ointment; Group 3 — the wound was exposed to photostimulation treated with methylene blue; Group 4 — physical activity in the postoperative period on a treadmill for 30 minutes; Group 5 — complex application of chitosan, photostimulation and physical activity. Wound healing was recorded by determining the area, photo-fixation of the wound was performed, and histological examinations of the skin and internal organs were performed. Obtained results: The best wound healing according to planimetry and histological studies was reliably noted in group 5 with the complex treatment of the surgical wound. Conclusions: The rehabilitation complex for large surgical wounds should include previously local effects of physiotherapeutic procedures and physical activity
Keywords
References
[1] Atai, Z., Atai, M., Amini, J., & Salehi, N. (2017). In vivo study of antifungal effects of low-molecular-weight chitosan against Candida albicans. Iranian Journal of Pharmaceutical Research, 59(3), 425-430. doi: 10.2334/josnusd.16-0295.
[2] Bolshakov, I.N., Fedyakina, S.P., & Chuyan, E.V. (2002). The use of chitosan in the treatment of inflammatory adhesive process in the abdominal cavity. Russian Bulletin of Surgery, Anesthesiology and Intensive Care, 22(2), 36-44.
[3] Camacho-Alonso, F., Julian-Belmonte, E., Chiva-Garcia, F., & Martinez-Beneyto, Y. (2017). Bactericidal efficacy of photodynamic therapy and chitosan in root canals experimentally infected with Enterococcus faecalis: An in vitro study. Photodiagnosis and Photodynamic Therapy, 17, 184-189. doi: 10.1089/pho.2016.4148.
[4] Gundel, O., Gundersen, S.K., Dahl, R.M., Jorgensen, L.N., Rasmussen, L.S., Wetterslev, J., & Meyhoff, C.S. (2018). Timing of surgical site infection and pulmonary complications after laparotomy. Acta Anaesthesiologica Scandinavica, 52, 56-60. doi: 10.1016/j.ijsu.2018.02.022.
[5] Uzakov, T.B., Uzakov, O.Zh., Belov, G.V., & Baibulatov, E.M. (2021). Influence of chitosan, photomodulation and physical exercises on the regeneration process of surgical wounds in the experiment. International Veterinary Bulletin, 7(10), 198-202.
[6] Zudina, I.V., Vedyaeva, A.P., Bulkina, N.V., Ivanov, P.V., & Alzubeidi, A.F.A. (2016). Studying the effect of chitosan on the process of bone defect healing in in vivo and in vitro experiments. The Genii of Orthopedics, 16(2), 171-179.