Abstract
In this experimental work, the effectiveness of Levomekol ointment based on polyethylene oxide gel in the prevention of abdominal adhesions in laboratory animals was evaluated. For work, 75 laboratory rats of both sexes weighing 180 grams, aged 14 days, were selected. As a research method, the method of a randomized parallel controlled study was used to improve the methods of intraoperative prevention of adhesions in the abdominal cavity. In the course of the study, a modified method for modeling the adhesive process of the abdominal cavity was used, followed by the introduction of anti-adhesive drugs (levomecol, 0.9% saline solution and Zhenchevskiy's anti-adhesion mixture). After autopsy of the animals 14 days after peritoneal suturing, the severity of the adhesive process was assessed according to a specially modified table. The results of the study proved the effectiveness of levomekol as an anti-adhesive agent
Keywords
References
[1] diZerega, G.S., & Tulandi, T. (2008). Prevention of intra-abdominal adhesions in gynaecological surgery. Reproductive Biomedicine Online, 17(3), 303-306. doi: 10.1016/s1472-6483(10)60211-8.
[2] Gaertner, W.B., Hagerman, G.F., Felemovicius, I., Bonsack, M.E., & Delaney, J.P. (2008). Two experimental models for generating abdominal adhesions. Journal of Surgical Research, 146(2), 241-245. doi: 10.1016/j.jss.2007.08.012.
[3] Hammoud, A., Gago, L.A., & Diamond, M.P. (2004). Adhesions in patients with chronic pelvic pain: A role for adhesiolysis? Fertility and Sterility, 82(6), 1483-1491. doi: 10.1016/j.fertnstert.2004.07.948.
[4] Kitaev, A.V., Ayrapetyan, A.T., & Turlay, D.M. (2016). Peritoneal adhesions in experiment. Prevention and treatment. Koloproktologiia, S1(55), article number 118a.
[5] Sopuev, A.A., Mamatov, N.N., Ovcharenko, K.E., Umurzakov, O.A., & Ibragimov, U.K. (2011). Evaluation of the effectiveness of various options for modeling the adhesive process of the abdominal cavity. Actual Problems of Humanitarian and Natural Sciences, 3, 327-332.
[6] Sopuev, A.A., Mamatov, N.N., Ormonov, M.K., Ernisova, M.E., Kudayarov, E.E., & Baurov, A.B. (2020). Etiology and pathogenesis of the adhesive process of the abdominal cavity (Literature review). Bulletin KGMA named afrer I.K. Akhunbaev, 3, 37-45.
[7] Sopuev, A.A., Ormonov, M.K., Kudayarov, E.E., Mambetov, A.K., Ibraev, D.Sh., & Dzhainakova, A.Zh. (2020). Some modern ideas about the postoperative adhesive process in the abdominal cavity. Scientific Review. Medical Sciences, 3, 21-28.
[8] Sotnikova, E.S., Britikov, V.N., & Andreev, A.A. (2017). Model of peritoneal adhesions. Youth Innovation Bulletin, 6(2), 9-10.
[9] Zhenchevsky, R.A. (1989). Adhesive disease. Moscow: Meditsina.